API and Intermediates Custom Services
At Hisun, we strive to develop long standing, strong relationships with companies in the pharmaceutical industry both on the human, as well as veterinary side, covering a broad range of therapeutic areas, including oncology, anti-Infective, and cardiovascular, etc. We provide services for complex advanced intermediates, and custom APIs. Our expansive GMP compliant facilities, state-of-the-art equipment, and extensive expertise can support our customer’s needs from early research through all phases of clinical development and commercial supply. Our highly skilled R&D team welcomes the opportunity to provide custom services. We apply our breadth of technologies, skilled workforce, and state-of-the-art facilities while leveraging a cost competitive base for the benefit or our clients and partners.
API and Intermediates Manufacturing
Multi-step Synthesis
Capability
- High potency molecules
- Cytotoxins
- Distillation
- Temperature range (-)100°C to 300°>C
- High pressure to 100 bars
- Industrial scale column chromatography
| Sample Reaction Types | |||
|---|---|---|---|
| Acetylation | Crystalization | Grignard | Oxidation |
| Acidification | Cyanation | Hydrazine cyclization | Peroxide oxidation |
| Alkylation | Cyclization | Hydrolysis | Phosphorus trichloride |
| Decarboxylic | Enzymatic esterification | Iodization | Reduction |
| Bromination | Epoxidation | Lithiation | Sulfonation |
| Butyl lithium | Esterification | Methoxylation | Sulfur derivatives use |
| Chlorination | Ethylene oxide | Methyl hyrazine reactioin | Suzuki |
| Coupling | Fluorination | Nitrations | Zinc reduction |
| Cryogenic reaction | Friedel Crafts | Nucleophilic acromatic (SNAr) | |
| Methods & Conditions | |||
|---|---|---|---|
| Distillation, Chromotagraphy | Evaporators-short path & thin film | Temerature:-100°C to 300°C | Pressure: Up to 100 bars |
Capacity
- More than 10 workshops, 50 chemical synthesis production lines.
- Over 680 reactors with a cpacity of 900m3
Fermentations
Capability
- Complex small molecule
- Downstream processing
- Bacteria, yest, Filamentous Fungi, Mammalian
Capacity
A wide range of fermenter, extraction extraction and purification capacities contribute to the flexibility for a variety of product campaigns
- Lab, Pilot, Commercial Scale
- Over 680 reactors from 20L to 8,000L
- >900m3 and 50 production lines
- >240 Fermenters from 1 to 80m3
- More than 8,000m3 of fermentation capacity
Natural Product
- Extraction
- Chemical modification
Protein Engineering
- Cell line development
- Cloning
- Protein expression and modification
